Interstitial Lipoprotein Trafficking via Lymphatics in Autoimmune Disease-the Surprising Role of the Immune System
4:00pm - 4:50pm
Classroom(2126A)

ABSTRACT



We studied that psoriasis-affected skin lesions program interleukin-17-producing T cells in draining lymph nodes to home to distal skin and later to arteries. There, these cells mediate thickening of the collagenous matrix, such that larger molecules including lipoproteins become entrapped, and increased vascular stiffness and atherosclerosis via this common pathway. Thus, interleukin-17 can reduce lipoprotein trafficking and increase vascular stiffness by, at least in part, remodeling collagen (Huang et al; 2019 Cell Metabolism). We also studied intestinal chylomicron transport through intestinal lymphatics in patients with Crohn’s disease and investigated how this process is regulated by dysregulated immune responses (Huang et al; 2020 Gastroenterology).

When
Where
Classroom(2126A)
Recommended For
Faculty and staff, PG students, UG students
Language
English
Speakers / Performers:
Lihao Huang
Fudan University
Organizer
Systems Hub, HKUST(GZ)
Science & Technology
RSS
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